Association between the 5-HTTLPR Polymorphism of the Serotonin Transporter Gene with the Efficiency and Tolerability of Selective Serotonin Reuptake Inhibitors

You are currently viewing a revision titled "Association between the 5-HTTLPR Polymorphism of the Serotonin Transporter Gene with the Efficiency and Tolerability of Selective Serotonin Reuptake Inhibitors", saved on 10 December 2018 at 9:52 pm EST by Юлия Волкова
Title
Association between the 5-HTTLPR Polymorphism of the Serotonin Transporter Gene with the Efficiency and Tolerability of Selective Serotonin Reuptake Inhibitors
Content
  • N. N. Ivanets
  • M. A. Kinkul’kina
  • Yu. G. Tikhonova
  • T. I. Avdeeva
  • A. A. Ragimov
  • N. G. Dashkova
  • O. E. Kuznetsov
  • A. V. Matveev
  • T. A. Izyumina
  • S. V. Orlov

Objective. To identify the association between the 5-HTTLPR polymorphism of the serotonin transporter gene with the efficacy and tolerability of antidepressant therapy with a selective serotonin reuptake inhibitor (SSRI).

Materials and methods. A complex clinical-psychopathological and genetic study of 38 patients with depression during SSRI treatment was conducted.

Results and conclusions. Statistical associations between the 5-HTTLPR polymorphism and the levels of remission and tolerability were identified: carriers of the SS genotype rarely achieved remission and developed more severe side effects.

Keywords

pharmacogenetics depression antidepressants 5-HTTLPR serotonin reuptake 
Excerpt
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Old New Date Created Author Actions
11 December 2018 at 2:53 am EST Юлия Волкова
11 December 2018 at 2:53 am EST Юлия Волкова
11 December 2018 at 2:52 am EST Юлия Волкова