The purpose of this work is to report the results of an experiment that examined gender differences in response to a chromatic saturation-like task. We measured contrast thresholds of 37 subjects (19 women, 18 men) to circular patches of uniform color—blue, green, yellow, and red—that alternated temporally with colored patches containing varying amounts of white. Based on previous findings, we predicted that more white would be required for women to disrupt the sensation of color. Women in our study did in fact have significantly higher contrast thresholds than men across all four colors (F = 7.82, p < 0.001) and at each color—blue (F = 6.59, p < 0.005), green (F = 6.42, p < 0.005), yellow (F = 8.30, p < 0.001) and red (F = 5.26, p < 0.01). The results reported here add to the body of evidence that women may rely more on chromatic processes than do men.