For the past half century, David Little has done path-breaking work in exploring the religious foundations and dimensions of human rights. While working on a wide interreligious canvas, he has focused in especially on some of the Calvinist foundations of human rights, notably in the work of John Calvin, John Locke, and Roger Williams. This chapter offers an appreciative appraisal of Little’s contributions, and shows its place in the emerging scholarship on Calvinism and law and on religion and human rights.