This article shows the high degree of correlation between the ways in which the right and the left hemispheres process and organize information and Whitehead’s understanding of the two pure and direct modes of perception, causal efficacy and presentational immediacy. The neuroscience is drawn from the recent work of Iain McGilchrist and Robert Ornstein. It is argued that the correlation supports the proposition that Whitehead’s metaphysics (of which his theory of perception is an integral part) can serve as the guiding metatheory for neuroscience.