Objective. To identify the association between the 5-HTTLPR polymorphism of the serotonin transporter gene with the efficacy and tolerability of antidepressant therapy with a selective serotonin reuptake inhibitor (SSRI).

Materials and methods. A complex clinical-psychopathological and genetic study of 38 patients with depression during SSRI treatment was conducted.

Results and conclusions. Statistical associations between the 5-HTTLPR polymorphism and the levels of remission and tolerability were identified: carriers of the SS genotype rarely achieved remission and developed more severe side effects.

Keywords: pharmacogenetics depression antidepressants 5-HTTLPR serotonin reuptake